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• Loratadine
• Wholesale 79794-75-5
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• ProName: Buy Reliable Quality Wholesale 79794-7...
• CasNo: 79794-75-5
• Molecular Formula: C22H23ClN2O2
• Application: Loratadine is an antihistamine used to...
• ProductionCapacity: Metric Ton/Day
• Purity: 99%
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Loratadine is available under various brand names, including Claritin, Claritin RediTabs, Children's Claritin, Loradamed, Non-Drowsy Allergy, Allerclear, and others. As a non-drowsy antihistamine, loratadine works by blocking histamine, a substance released by the body during allergic reactions. By inhibiting histamine's effects, loratadine helps alleviate common allergy symptoms.

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It's important to note that loratadine may still cause slight drowsiness in some individuals. Children, in particular, may experience headaches, fatigue, or nervousness after taking loratadine. It's advisable to refrain from consuming alcohol while taking loratadine, as it may enhance feelings of sleepiness.

The best time to take loratadine depends on the timing of allergy symptoms. If symptoms are worse in the morning, taking loratadine the night before might be beneficial. Conversely, if symptoms are more pronounced at night, taking loratadine in the morning may be preferable. Loratadine typically reaches peak plasma concentration within 1-2 hours, and its effects last for at least 24 hours. Once-daily dosing is recommended.

Certain precautions should be taken when using loratadine. Patients are advised not to take loratadine with other central nervous system (CNS) depressants, as it may lead to dose-related sedation. Additionally, limiting or avoiding caffeine intake is recommended when using loratadine in combination with pseudoephedrine, as this combination may raise the risk of side effects such as a fast heart rate, high blood pressure, and difficulty sleeping.

References of Loratadine 79794-75-5

Loratadine: A Preliminary Review of its Pharmacodynamic Properties and Therapeutic Efficacy

Stephen P. Clissold, Eugene M. Sorkin & Karen L. Goa

Drugs, 37, pages42–57 (1989)

Loratadine is a long acting antihistamine which has a high selectivity for peripheral histamine H1-receptors and lacks the central nervous system depressant effects often associated with some of the older antihistamines. The recommended adult dosage of loratadine is 10mg once daily while that of the combination tablet (loratadine 5mg plus pseudoephedrine 120mg) is 1 tablet twice daily.

Pharmacokinetics and Dose Proportionality of Loratadine

James Hilbert PhD, Elaine Radwanski PhD, Ray Weglein PhD, Van Luc, George Perentesis PharmD, Samson Symchowicz PhD, Nicola Zampaglione PhD

The Journal of Clinical Pharmacology, Volume27, Issue9 September 1987 Pages 694-698

The dose proportionality and pharmacokinetics of loratadine, a new nonsedating antihistamine, were studied in 12 normal volunteers. Loratadine and descarboethoxyloratadine plasma concentrations and pharmacokinetics were not dose dependent.