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CAS NO.58909-39-0
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Thiotriazinone binds to the cell wall of bacteria through hydrogen bonding with the nitrogen atoms of the amino groups in peptidoglycan.
It competitively inhibits the enzyme D-alanine: D-alanine ligase, a key enzyme involved in the synthesis of cell wall peptidoglycan. This inhibitory action disrupts bacterial cell wall synthesis, leading to the inhibition of bacterial growth.
Solubility of Thiotriazinone in Binary Solvent Mixtures of Water + Methanol and Water + Ethanol from (283 to 330) K
Haiyan Ma†, Yixin Qu*†, Zhimao Zhou†, Shui Wang†, and Lizhong Li‡J.
Chem. Eng. Data 2012, 57, 8, 2121–2127
The solubility of thiotriazinone in water, methanol, ethanol, water + methanol, and water + ethanol has been measured under temperatures ranging from (283 to 330) K with a laser technique. The results of these measurements were correlated with semiempirical equations. The calculated results have showed fine representativity of experimental data. The stepwise regression method was used to simplify the modified Jouyban–Acree equation.
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