Keywords

• (S)-4-Chloro-3-Hydroxybutyronitrile
• 99% Pure 127913-44-4
• 127913-44-4 Low Price

Quick Details

• ProName: Chinese Manufacturer Supply 99% Pure 1...
• CasNo: 127913-44-4
• Molecular Formula: C4H6ClNO
• Application: (S)-4-Chloro-3-hydroxybutyronitrile is...
• ProductionCapacity: Metric Ton/Day
• Purity: 99%
• LimitNum: 0 Metric Ton

Superiority

Chinese Manufacturer Supply 99% Pure 127913-44-4 with Low Price, accept customization.

Details

(S)-4-Chloro-3-Hydroxybutyronitrile can be purchased online for pharmaceutical testing.

Chinese Manufacturer Supply 99% Pure (S)-4-Chloro-3-Hydroxybutyronitrile 127913-44-4 with Low Price

Classification: Synthetic chemical
Use: Feedstock in the manufacture of pleuromutilin derivatives

(Applications):

Synthesis of Organic Precursors:

Used in the synthesis of hydroxypyrrolidinones.
Hydroxypyrrolidinones serve as carbapenem precursors.

Atorvastatin Precursor:

Used in the preparation of atorvastatin (A791750) precursors.
Atorvastatin is a medication used to lower cholesterol and prevent cardiovascular disease.
Chiral Building Block:

(S)-4-Chloro-3-hydroxybutyronitrile [(S)-CHBN] serves as a chiral building block.

(Availability):

Can be purchased online for pharmaceutical testing.
(Significance):

Used as a key intermediate in the synthesis of pleuromutilin derivatives.
Plays a role in the preparation of atorvastatin, a widely used cholesterol-lowering medication.

(Additional Information):

CHB is employed as a building block in the synthesis of various organic compounds due to its chiral nature.

References of (S)-4-Chloro-3-Hydroxybutyronitrile 127913-44-4

Production of (S)-4-chloro-3-hydroxybutyronitrile using microbial resolution

Toshio Suzuki ∗, Hideaki Idogaki, Naoya Kasai ∗

Bioorganic & Medicinal Chemistry Letters Volume 6, Issue 21, 5 November 1996, Pages 2581-2584

A new production procedure of (S)-4-chloro-3-hydroxybutyronitrile was developed using microbial resolution. The resting cells of Pseudomonas sp. OS-K-29 preferentially converted (R)-4-chloro-3-hydroxybutyronitrile to the corresponding 1,2-diol by the dehalogenating activity so that (S)-4-chloro-3-hydroxybutyronitrile (94.5 %ee) was obtained from the racemate in 40 % yield at the microbial resolution step.

A One-Step Biocatalytic Process for (S)-4-Chloro-3-hydroxybutyronitrile using Halohydrin Dehalogenase: A Chiral Building Block for Atorvastatin

Dr. Nan-Wei Wan, Prof. Zhi-Qiang Liu, Dr. Feng Xue, Zhen-Yang Shen, Prof. Yu-Guo Zheng

ChemCatChem, 2015, Volume7, Issue16 August 17, 2015 Pages 2446-2450

A novel one-step process for the preparation of (S)-4-chloro-3-hydroxybutyronitrile from 1,3-dichloro-2-propanol is developed by using the halohydrin dehalogenase HheC from Agrobacterium radiobacter AD1. By using the mutant HheC-W249F and a substrate loading of 10 g L−1, the product is obtained in 86 % yield with 97.5 % ee.