Keywords

• Ethyl (R)-(-)-4-Cyano-3-Hydroxybutyate
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Quick Details

• ProName: Buy Reliable Quality 141942-85-0, Offe...
• CasNo: 141942-85-0
• Molecular Formula: C7H11NO3
• Application: Ethyl (R)-(-)-4-cyano-3-hydroxybutyrat...
• ProductionCapacity: Metric Ton/Day
• Purity: 99%
• LimitNum: 0 Metric Ton

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Details

Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate (HN) is a significant chiral synthon with various applications in the synthesis of pharmaceutical compounds.

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Properties:

Assay: 95%
Boiling Point (BP): 270 °C
Density: 1.114 g/mL at 25 °C
Storage Temperature: 2-8°C

Other Applications:

HN is utilized in the production of L-carnitine, a compound involved in energy metabolism.
It is also used in the synthesis of (R)-4-amino-3-hydroxybutanoic acid.

Stereochemistry:

Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate has a specific stereochemistry denoted by "(R)-(-)," indicating a particular three-dimensional arrangement and optical rotation.

References of Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate 141942-85-0

A New Practical Synthesis of Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate From (S)-3-chloro-1,2-propanediol

Jiang, Chengjun; Hong, Huabin

Letters in Organic Chemistry, Volume 9, Number 7, 2012, pp. 520-521(2)

A practical chemical synthesis of ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate((R)-CNHB) has been accomplished from (S)-3-chloro-1,2-propanediol, which is a main by-product originating from (S,S)-Salen Co(III) catalyzed by hydrolytic kinetic resolution (HKR) of epichlorohydrin. The new synthetic approach demonstrated an efficient utilization of organic by-product for the asymmetric synthesis of the intermediate of atorvastatin.

Synthesis of ethyl (R)-4-cyano-3-hydroxybutyrate in high concentration using a novel halohydrin dehalogenase HHDH-PL from Parvibaculum lavamentivorans DS-1

Nan-Wei Wan,ab   Zhi-Qiang Liu,ab   Kai Huang,ab   Zhen-Yang Shen,ab   Feng Xue,ab   Yu-Guo Zheng*ab  and  Yin-Chu Shenab

RSC Advances, Issue 109, 2014

We identified and characterized a novel halohydrin dehalogenase HHDH-PL from Parvibaculum lavamentivorans DS-1. Study of substrate specificity indicated that HHDH-PL possessed a high activity toward ethyl (S)-4-chloro-3-hydroxybutanoate ((S)-CHBE). After optimizations of the pH and temperature, whole cell catalysis of HHDH-PL was applied to the synthesis of ethyl (R)-4-cyano-3-hydroxybutyrate (HN) at 200 g L−1 of (S)-CHBE, which gave 95% conversion and 85% yield in 14 h.

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