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CAS NO.141942-85-0
Buy Reliable Quality 141942-85-0, Offer Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate with Efficient Shipping, accept customization.
Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate (HN) is a significant chiral synthon with various applications in the synthesis of pharmaceutical compounds.
Properties:
Assay: 95%
Boiling Point (BP): 270 °C
Density: 1.114 g/mL at 25 °C
Storage Temperature: 2-8°C
Other Applications:
HN is utilized in the production of L-carnitine, a compound involved in energy metabolism.
It is also used in the synthesis of (R)-4-amino-3-hydroxybutanoic acid.
Stereochemistry:
Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate has a specific stereochemistry denoted by "(R)-(-)," indicating a particular three-dimensional arrangement and optical rotation.
A New Practical Synthesis of Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate From (S)-3-chloro-1,2-propanediol
Jiang, Chengjun; Hong, Huabin
Letters in Organic Chemistry, Volume 9, Number 7, 2012, pp. 520-521(2)
A practical chemical synthesis of ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate((R)-CNHB) has been accomplished from (S)-3-chloro-1,2-propanediol, which is a main by-product originating from (S,S)-Salen Co(III) catalyzed by hydrolytic kinetic resolution (HKR) of epichlorohydrin. The new synthetic approach demonstrated an efficient utilization of organic by-product for the asymmetric synthesis of the intermediate of atorvastatin.
Synthesis of ethyl (R)-4-cyano-3-hydroxybutyrate in high concentration using a novel halohydrin dehalogenase HHDH-PL from Parvibaculum lavamentivorans DS-1
Nan-Wei Wan,ab Zhi-Qiang Liu,ab Kai Huang,ab Zhen-Yang Shen,ab Feng Xue,ab Yu-Guo Zheng*ab and Yin-Chu Shenab
RSC Advances, Issue 109, 2014
We identified and characterized a novel halohydrin dehalogenase HHDH-PL from Parvibaculum lavamentivorans DS-1. Study of substrate specificity indicated that HHDH-PL possessed a high activity toward ethyl (S)-4-chloro-3-hydroxybutanoate ((S)-CHBE). After optimizations of the pH and temperature, whole cell catalysis of HHDH-PL was applied to the synthesis of ethyl (R)-4-cyano-3-hydroxybutyrate (HN) at 200 g L−1 of (S)-CHBE, which gave 95% conversion and 85% yield in 14 h.
Tianjin Kind Pharma Co., Ltd. is a good Chinese Factory of Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate (CAS Number: 141942-85-0), We offer 141942-85-0 with Efficient Shipping.